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The Disease Signalling Group
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Biography

Publications

CV

  

 

The disease signalling group (DSG), headed by Prof. Anna-Mart Engelbrecht aims to be a cutting-edge research group on the South African and international arena. We strive to ask key questions that will further develop science and enable us to make an impact at the forefront of scientific development and innovation. Our work is hypothesis driven and we aim to tackle science in a professional manner. We communicate our work through publications in scientific journals, and also exchange ideas and expose ourselves to novel research by being present at key national and international conferences.

The group includes senior doctoral students as well as student on MSc and Hons level. It provides an environment for growth and promotes team building, through dedication and hard work. The group also exposes its students to novel techniques, preparing them for world class scientific careers.

 

Research focus

Our main research focus is on autophagy and the signalling mechanisms involved in cancer and cardiovascular disease.

 

Current projects include

  • Anthracycline-induced cardiotoxicity- role of the ubiquitin-proteasome pathway (UPP) and autophagy
  • Therapeutic nutrient starvation and breast cancer: The effect of increased basal autophagy on doxorubicin treatment regimes.
  • An investigation into the various modes of cell death in the progressive stages of cervical carcinoma
  • The role of MKP-1 in myocardial ischaemia/reperfusion (I/R) injury

 

Current Students

Gina Leisching (PhD); Heloise le roux (MSc), Justin Mills (MSc)

 
   

 

 

 

 

 

2011 Team

  2012

Team