Databases:

ResearcherID: G-1783-2010

Research papers (Independent):

23. Lamprecht DA, Muneri NO, Eastwood H, Naidoo KJ, Strauss E* and Jardine A.* An enzyme-initiated Smiles rearrangement enables the development of an assay of MshB, the GlcNAc-Ins deacetylase of mycothiol biosynthesis. Org. Biomol. Chem. (2012), DOI: 10.1039/c2ob25429h.
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22. Van der Westhuyzen R, Hammons JC, Meier JL, Dahesh S, Moolman WJA, Pelly SC, Nizet V, Burkart MD* & Strauss E.* The Antibiotic CJ-15,801 is an Antimetabolite which Hijacks and then Inhibits CoA Biosynthesis. Chem. Biol. 19, 559–571 (2012).
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• Highligted in Chem. Biol. 19, 543–545 (2012). Read Paper
20. Abrie JA, González A, Strauss E* & Ariño J.* Functional Mapping of the Disparate Activities of the Yeast Moonlighting Protein Hal3. Biochem. J. 442, 357-368, (2010).
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21. Strauss E.* Grand Challenges Commentary: Exploiting single-cell variation for new antibiotics. Nature Chem. Biol. 6, 873-875, (2010).
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19. Van der Westhuyzen R & Strauss E.* Michael Acceptor-Containing Coenzyme A Analogues As Inhibitors of the Atypical Coenzyme A Disulfide Reductase from Staphylococcus aureus. J. Am. Chem. Soc. 132, 12853-12855, (2010).
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18. Rootman I, de Villiers M, Brand LA & Strauss E.* Creating Cellulose-Binding Domain Fusions of the Coenzyme A Biosynthetic Enzymes to Enable Reactor-Based Biotransformations. ChemCatChem 2, 1239-1251, (2010).
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17. De Villiers J, Koekemoer L & Strauss E.* 3-Fluoroaspartate and Pyruvoyl-Dependant Aspartate Decarboxylase: Exploiting the Unique Characteristics of Fluorine To Probe Reactivity and Binding. Chem. Eur. J. 16, 10030-10041, (2010).
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16. Ruiz A, González A, Munoz I, Serrano R, Abrie JA, Strauss E & Ariño J.* Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nature Chem. Biol. 5, 920-928, (2009).
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• Highligted in Nature Chem. Biol. 5, 871-872, (2009) Read Paper; Faculty of 1000.
15. Yang K, Strauss E, Huerta C & Zhang H.* Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase. Biochemistry 47, 1369-1380, (2008).
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14. Van Wyk M. & Strauss E.* Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization. Org. Biomol. Chem. 6, 4348-4355, (2008).
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13. Van Wyk M & Strauss E.* One-pot preparation of coenzyme A analogues via an improved chemoenzymatic synthesis of pre-CoA thioester synthons. Chem. Commun., 398-400, (2007).
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12. Yang K, Eyobo Y, Brand LA, Martynowski D, Tomchick D, Strauss E* & Zhang H.* Crystal structure of a type III pantothenate kinase: Insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria. J. Bateriol. 188, 5532-5540, (2006).
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11. Strauss E* & Begley TP.* The selectivity for cysteine over serine in coenzyme A biosynthesis. ChemBioChem 6, 284-286, (2005).
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10. Brand LA & Strauss E.* Characterization of a new pantothenate kinase isoform from Helicobacter pylori. J. Biol. Chem. 280, 20185-20188, (2005).
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9. Strauss E,* Zhai H, Brand LA, McLafferty FW & Begley TP.* Mechanistic studies on phosphopantothenoylcysteine decarboxylase: Trapping of an enethiolate intermediate with a mechanism-based inactivating agent. Biochemistry 43, 15520-15533, (2004).
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Research papers (Graduate & Undergraduate):

8. Strauss E & Begley TP. Stereochemical studies on phosphopantothenoylcysteine decarboxylase from Escherichia coli. Bioorg. Med. Chem. Lett. 13, 339-342 (2003).
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7. Seravalli J, Gu WW, Tam A, Strauss E, Begley TP, Cramer SP & Ragsdale SW. Functional copper at the acetyl-CoA synthase active site. Proc. Natl. Acad. Sci. U.S.A. 100, 3689-3694, (2003).
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6. Manoj N, Strauss E, Begley TP & Ealick SE. Structure of human phosphopantothenoylcysteine synthetase at 2.3 angstrom resolution. Structure 11, 927-936, (2003).
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5. Strauss E & Begley TP. The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme A, a coenzyme A antimetabolite. J. Biol. Chem. 277, 48205-48209, (2002).
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4. Ge Y, Lawhorn BG, ElNaggar M, Strauss E, Park J-H, Begley TP & McLafferty FW. Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry. J. Am. Chem. Soc. 124, 672-678, (2002).
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3. Strauss E, Kinsland C, Ge Y, McLafferty FW & Begley TP. Phosphopantothenoylcysteine synthetase from Escherichia coli - Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria. J. Biol. Chem. 276, 13513-13516 (2001).
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2. Strauss E & Begley TP. Mechanistic studies on phosphopantothenoylcysteine decarboxylase. J. Am. Chem. Soc. 123, 6449-6450 (2001).
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1. Mafunda BG, Modro AM, Modro TA, Strauss E & Strydom CA. Thermal fragmentation of 2-chloropentylphosphonic salts in the solid state. Counter-ion effects on reactivity and selectivity. Heteroatom Chem. 8, 421-428 (1997).
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Reviews:

2. Strauss E,* de Villiers M & Rootman I. Biocatalytic Production of Coenzyme A Analogues. ChemCatChem 2, 929-937, (2010).
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1. Spry C, van Schalkwyk DA, Strauss E & Saliba KJ.* Pantothenate utilization by plasmodium as a target for antimalarial chemotherapy. Infect. Disord. Drug Targets 10, 200-216 (2010).
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Book Chapters:

2. Begley TP, Kinsland C & Strauss E. The biosynthesis of coenzyme A in bacteria, in Vitamins and Hormones - Advances in Research and Applications, Vol 61, 157-171 (2001).
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1. Strauss E.* Coenzyme A Biosynthesis and Enzymology, in Comprehensive Natural Products II Chemistry and Biology Vol. 7 (Eds. Lew Mander & Hung-Wen Liu) 351-410 (Elsevier, 2010).
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