Conference Programme
Animating the Cellular Map
9th International BioThermoKinetics Meeting
[Monday 3 April] [Tuesday 4 April] [Wednesday 5 April]
[Thursday 6 April] [Friday 7 April]
The image of traffic on a dynamic cellular map is used as an organising principle for the BTK2000 programme. This framework integrates theory and experiment. Therefore, we do not include separate sessions for control (analysis), regulation, kinetics, self-organisation, etc., but rather ask participants to weave these topics into their contributions.
Because this meeting is smaller than previous BTKs, every participant will have the opportunity to present a lecture. Participants are welcome to bring posters; there will be space for putting them up. We will organise formal poster sessions if necessary.
The evenings will be of a more informal nature, featuring round-table discussions of "hot topics". A number of discussions have already been suggested (see topics below). The schedule for round-table discussions will be finalised later; further discussions may also be arranged on an ad hoc basis at the meeting.
Suggestions for round-table topics received so far:
- What (if anything) is a metabolic pathway?
- Specifying a standard metabolic language for modelling and data storage
- Promoting the BTK Research Programme in the new millennium
Monday 3 April
Opening session
(chaired by Jannie Hofmeyr) |
| 17:30 |
Official opening of BTK2000 |
| 17:45 |
Opening lecture: Hans Westerhoff
A new millenium: functional genomics, cellular bioinformatics, regulation analysis [PDF file] |
| 19:30 |
Dinner and social get-together |
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Tuesday 4 April
Session I: Metabolic traffic in vivo
(chaired by Jean-Pierre Mazat) |
| 09:00 |
Eva Albers
Product formation and protein expression of Saccharomyces cerevisiae during growth on glutamate as nitrogen source [PDF file] |
| 09:20 |
Fred Boogerd
What controls the growth rate of Escherichia coli? Is it transport after all? [PDF file] |
| 09:40 |
Simon Eaton
Carnitine palmitoyl transferase I and malonyl-CoA in the heart and skeletal muscle: does control analysis help to explain the paradox? [PDF file] |
| 10:00 |
Coffee/tea break |
| 10:30 |
Ezzatollah Keyhani
Kinetics of isoperoxidases and their differential sensitivity to inhibitors in saffron (Crocus sativus L.) bulb [PDF file] |
| 10:50 |
Claus Rix Melchiorsen
Dynamics of pyruvate metabolism in Lactococcus lactis [PDF file] |
| 11:10 |
Karin Reijenga
Control of metabolic dynamics: How the frequency of glycolytic oscillations in Saccharomyces cerevisiae is controlled by glucose transport [PDF file] |
| 11:30 |
General discussion: Session I
(introduced by David Fell) |
| 12:30 |
Lunch |
Session II: Metabolic traffic in silico
(chaired by Judit Ovádi) |
| 15:00 |
Fazoil Ataullakhanov
Metabolic trigger: control of the methionine metabolism [PDF file] |
| 15:20 |
Athel Cornish-Bowden
Irreversible reactions in metabolic simulations: how reversible is irreversible? [PDF file] |
| 15:40 |
Oliver Ebenhöh
Reconstruction of the stoichiometry of ATP and NADH producing systems using evolutionary algorithms [PDF file] |
| 16:00 |
Coffee/tea break |
| 16:30 |
David Fell
Structural properties of metabolic networks: implications for evolution and modelling of metabolism [PDF file] |
| 16:50 |
Andrei Plotnikov
Molecular mechanism of increase 2,3-DPG concentration in human erythrocytes at high altitude [PDF file] |
| 17:10 |
Oscar Somsen
An in vivo assay for metabolic regulation? [PDF file] |
| 17:30 |
General discussion: Session II
(introduced by Lena Gustafsson) |
| 18:30 |
Dinner |
| 20:30 |
Round table discussion I |
[Top of page]
Wednesday 5 April
Session III: Energy traffic
(chaired by Peter Ruhdal Jensen) |
| 09:00 |
Philippe Diolez
Top down analysis of heart bioenergetics [PDF file] |
| 09:20 |
Jacqueline Hoerter
Organization of the CK system in the perfused rat heart [PDF file] |
| 09:40 |
Wieslawa Jarmuszkiewicz
Efficiency of A. castellanii uncoupling protein in energy-dissipating processes [PDF file] |
| 10:00 |
Coffee/tea break |
| 10:30 |
Jean-Pierre Mazat
Metabolic control analysis and threshold effect in oxidative phosphorylation: study in an intermediate state of respiration [PDF file] |
| 10:50 |
Francis Sluse
Proton partitioning between ATP synthase and uncoupling protein during cytochrome pathway state 3 respiration in tomato fruit mitochondria [PDF file] |
| 11:10 |
Sybille Soboll
Determination of creatine kinase fluxes in heart mitochondria using 31P-saturation-transfer-NMR [PDF file] |
| 11:30 |
General discussion: Session III
(introduced by Johann Rohwer) |
| 12:30 |
Lunch |
| Afternoon: Excursions |
| 18:30 |
Dinner |
| 20:30 |
Round table discussion II |
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Thursday 6 April
Session IV: Signal traffic
(chaired by Philippe Diolez) |
| 09:00 |
Martin Brand
Control analysis of signal transduction [PDF file] |
| 09:20 |
Frank Bruggeman
Is the signal transduction network emanating from the EGF receptor bistable in vivo? [PDF file] |
| 09:40 |
Edda Klipp
Reprogramming of metabolic systems by altering gene expression [PDF file] |
| 10:00 |
Coffee/tea break |
| 10:30 |
Ursula Kummer
Robustness in a model for calcium signal transduction dynamics [PDF file] |
| 10:50 |
Judit Ovádi
Supramolecular organization-dependent responses to stimuli [PDF file] |
| 11:10 |
Jacky Snoep
Hierarchical control of DNA supercoiling in Escherichia coli: how to study homeostatically controlled systems using control analysis [PDF file] |
| 11:30 |
General discussion: Session IV
(introduced by Hans Westerhoff) |
| 12:30 |
Lunch |
Session V: Modelling the traffic on the map: concepts and tools
(chaired by Reinhart Heinrich) |
| 15:00 |
Alberto de la Fuente van Bentem
Can Metabolic Control Analysis be applied to hierarchical regulated metabolism? MCA versus HCA [PDF file] |
| 15:20 |
Jannie Hofmeyr
From mushrooms to isolas: surprising behaviour in a simple biosynthetic system subject to end-product inhibition [PDF file] |
| 15:40 |
Pedro Mendes
PathDB: a second generation metabolic database [PDF file] |
| 16:00 |
Coffee/tea break |
| 16:30 |
Johann Rohwer
Assessing the control of fermentative free-energy metabolism in yeast: a modelling exploration [PDF file] |
| 16:50 |
Herbert Sauro
Jarnac: a system for interactive metabolic analysis [PDF file] |
| 17:10 |
Stefan Schuster
Topological analysis of metabolic networks. Application to the metabolism of Mycoplasma pneumoniae [PDF file] |
| 17:30 |
General discussion: Session V
(introduced by Athel Cornish-Bowden) |
| 18:30 |
Dinner |
| 20:30 |
Round table discussion III |
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Friday 7 April
Session VI: Modelling the traffic on the map: real systems
(chaired by Jacqueline Hoerter) |
| 09:00 |
Reinhart Heinrich
Mathematical modelling of posttranslational protein translocation [PDF file] |
| 09:20 |
Marcel Hoefnagel
Modeling pyruvate distribution in L. lactis: A kinetic model to aid metabolic engineering [PDF file] |
| 09:40 |
Mark Poolman
Modelling and experimental evidence for two separate steady states in the photosynthetic calvin cycle [PDF file] |
| 10:00 |
Coffee/tea break |
| 10:30 |
Victor Vitvitsky
Cell membrane chloride permeability as a regulator of the cell volume in permeabilised human erythrocytes [PDF file] |
| 10:50 |
General discussion: Session VI
(introduced by Stefan Schuster) |
| 11:20 |
BTK General Meeting and election of new Chairperson |
| 12:30 |
Lunch |
Session VII: Manipulating dynamic behaviour
(chaired by Martin Brand) |
| 15:00 |
Heidi Winterberg Andersen
The importance of balanced expression of glycolytic genes in Lactococcus lactis [PDF file] |
| 15:20 |
Jasper Diderich
High affinity glucose transport in Saccharomyces cerevisiae deleted in hexokinase II [PDF file] |
| 15:40 |
Philip Groeneveld
Modular Control Analysis: Are membranes or cytosol more important for growth of the industrial yeast Kluyveromyces marxianus? [PDF file] |
| 16:00 |
Coffee/tea break |
| 16:30 |
Jeroen Hugenholtz
Metabolic engineering of lactic acid bacteria for the improvement of fermented dairy products [PDF file] |
| 16:50 |
Peter Ruhdal Jensen
Hemin reconstitutes the growth of an H+-ATPase negative mutant of Lactococcus lactis [PDF file] |
| 17:10 |
Brian Koebmann
Is the glycolytic flux in L. lactis controlled by glycolysis itself? [PDF file] |
| 17:30 |
General discussion: Session VII
(introduced by Jacky Snoep) |
| 18:30 |
Closing ceremony
Conference banquet |
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Links
These pages are being compiled by
Johann Rohwer.
Last update 10 March 2000.
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